Studies Dual Rinse HEDP®
Cyotoxicity of Etidronate as an Endodontic Chelator Against Periodontal Ligament Fibroblast
Vila Nova de Almeida B, Sueli da Silva Kataoka M, de Almeida Rodrigues P, de Jesus Viana Pinheiro J, Pereira Mitre G, Tartari T, Faciola Pessoa O
Australian Endodontic Journal, 2025; 0:1–8
Effect of EDTA, NaOCl, and HEDP-based irrigants on the mechanical properties of heat treated NiTi endodontic instruments
Jeanne Davril J, Balthazard R, Hocquel R, Reynaud A, Mortier É and Vincent M
BDJ OPEN
Physical and Chemical Properties of All-in-One Root Canal Irrigants: A Laboratory Study
Gupta S, Narkedamalli R, Shetty PS, Ballal NV
European Journal of Dentistry
https://doi.org/10.1055/s-0045-1812107
ISSN 1305-7456.
Dentine Integrity and Shaping Ability of 3 Single-File Systems in Flat-Shaped Canals
Belladonna FG, Solomonov M, De-Deus G, Souza E, Frota RR, Silva EJ, Ben-Itzhak, Versiani M
International Endodontic Journal, 2025; 0:1–11
Evaluation of the effects of traditional irrigation solutions and etidronic acid on the bond strength of endodontic sealers
Emekli GE, Kaptan RF, Tanalp J
BMC Oral Health (2025) 25:364
Continuous Chelation Reduces Instrumentation Time and Straightening of Double-curved Simulated Root Canals in Bovine Dentin
Hofpeter K, Zehnder M, Solomonov M, Deari S
Journal of Endodontics
Solutes in water affect the primary cavitation bubble generated by a pulsed erbium-doped yttrium aluminium garnet laser
Meire M, van Aelst B , Sehovic A, Deari S, Zehnder M
Lasers in Medical Science (2024) 39:298
Compatibility of Dual Rinse 1-Hydroxyethane- 1,1-Diphosphonic Acid with Sodium Hypochlorite Solutions Containing Proprietary Additives
Honey Kottathil H, Zehnder M,* Gubler A, Attin T, Narkedamalli R, Ballal NV,
Journal of Endodontics
https://doi.org/10.1016/j.joen.2024.07.007
https://www.sciencedirect.com/science/article/pii/S0099239924004023?via%3Dihub
Effect of continuous vs sequential chelation on the mechanical properties of root dentin: An ex vivo study
Ballal NV, Ray AB, Narkedamalli R, Urala AS, Patel V, Harris M, Bergeron BE, Tay FR
Journal of Dentistry 148 (2024) 105214
Evaluation of pH and Optical Properties of Dual Rinse HEDP Irrigating Solution
Simic, A.; Papic, M.V.; Nikitovic, A.; Kocovic, A.; Petrovic, R.; Melih, I.; Zivanovic, S.; Papic, M.; Popovic, M.
Appl. Sci. 2024, 14, 1675.
https://doi.org/10.3390/app14041675
The Effect of Different Compositions and Concentrations of Etidronate-Containing Irrigants on the Antibacterial Activity of Sodium Hypochlorite against Enterococcus faecalis and Candida albicans
Novozhilova N, Babina K, Polyakova M, Sokhova I, Sherstneva V, Zaytsev A, Makeeva I, Mikheikina A
Dent. J. 2024, 12(3), 46
https://doi.org/10.3390/dj12030046
Dislodgement resistance and structural changes of tricalcium silicate-based cements after exposure to different chelating agents
Ulusoy Öi, Ballal NV, Narkedamalli R, Ulusoy N, Shetty KP, Luke AM
PLoS ONE 19 (1): e0296647 2024 Jan. 17
https://doi.org/10.1371/journal.pone.0296647
Effect of two methods of irrigant agitation on the temperature and cleanliness of sodium hypochlorite associated or not with a chelator
Borges MMB, Barros MC de, Queiroz Índia O de A, Andrade FB de, Duarte MAH
Braz. J. Oral Sci. [Internet]. 2023 Aug. 25 [cited 2023 Sep. 14];22(00):e238692. Available from:
https://periodicos.sbu.unicamp.br/ojs/index.php/bjos/article/view/8668692
Effectiveness of continuous chelation irrigation protocol in endodontics: a scoping review of laboratory studies
La Rosa GRM, Plotino G, Nagendrababu V, Pedullà E
Odontology (2023)
Effect of continous chelation on the dentinal tubule penetration of a calcium silicate-based root canal sealer: a confocal laser microscopy study
Hassan, R; Roshdy, NR
BMC Oral Health (2023) 23:377
Effect of Continuous Chelation Irrigation Using Dual Rinse HEDP+3% NaOCl with or without High-power Sonic Activation on Debris and Smear Layer Removal
Aoun C, Rechenberg DK, Karam M, Mhanna R, Plotino G, Zogheib C
European Endodontic Journal
Effects of continuous chelation on the instrumentation of curved canals with a martensitic NiTi file system: an ex vivo micro-CT evaluation
Sobrino, M., Foschi, F., Estévez, R. et al.
Odontology (2022)
Enhancing the intracanal antibacterial effects of sodium hypochlorite with etidronic acid or citric acid
Campello A, Rodrigues RCV, Alves FRF, Miranda KR, Brum SC, Mdala I, MSc, Siqueira JF, Jr., Rôças IN
Journal of Endodontics
Influence of dual rinse irrigation on dentinal penetration of a bioceramic root canal sealer: A Conofocal microscopic Analysis
Effect of exposure to etidronic acid on the bond strength of calcium silicate-based cements after 1 and 21 days: an in vitro study
Rebolloso de Barrio E , Pérez‐Higueras JJ, García‐Barbero E, Gancedo‐Caravia L
BMC Oral Health (2021) 21:591
https://doi.org/10.1186/s12903-021-01959-5 (open access)
Effect of Sodium Hypochlorite Concentration in Continuous Chelation on Dislodgement Resistance of an Epoxy Resin and Hydraulic Calcium Silicate Sealer
Ballal NV, Roy M, Zehnder M
https://doi.org/10.3390/polym13203482 (open access)
Influence of 1-Hydroxyethylidene-1,1-Diphosphonic Acid on the Soft Tissue-Dissolving and Gelatinolytic Effect of Ultrasonically Activated Sodium Hypochlorite in Simulated Endodontic Environments
Ballal V, Ivica A, Meneses P, Narkedamalli K, Attin T, Zehnder M
Materials 2021, 14(10), 2531
https://doi.org/10.3390/ma14102531 (open access)
Immediate and Delayed Bond Strength of a Multimode Adhesive to Deep Coronal Dentin Following Different Root Canal Irrigation Regimens
Spicciarelli V, Neelakantan P, Cantini E, Marzocco D, Ounsi H, Marrugantie C, Grandini S
J Adhes Dent 2021; 23: 167–175.
Efficacy of EDTA and HEDP Chelators in the Removal of Mature Biofilm of Enterococcus faecalis by PUI and XPF File Activation
lvarez-Sagües, A.; Herce, N.; Amador, U.; Llinares-Pinel, F.; Nistal-Villan, E.; Presa, J.; Álvarez, L.; Azabal, M.
Dent. J. 2021, 9, 41.
SEM and energy dispersive X-ray evaluation of smear layer removal using standard and innovative irrigation protocols: a comparative in vitro study
Lamia Ahmed Ibrahim, Hala Fayek Khalil
Egyptian Dental Journal (VOL.67, 861:869, January, 2021
DOI: 10.21608/edj.2021.45671.1350
https://edj.journals.ekb.eg/article_144099_fdd69c57b56cb9e9907643a98d0a15ca.pdf
The effects of sequential and continuous chelation on dentin
Rath PP, Yiu CKY, Matinlinna JP, Kishen A, Neelakantan P
Dent Mat (2020)
Etidronate (Dual Rinse HEDP) for root canal irrigation in clinical use
Quintessenz Zahnmedizin (08/19)
Author: Prof. Dr. Matthias Zehnder
https://www.medcem.eu/files/content/pdfs/SD_Zehnder_QD_19_08_engl.pdf
Cleanliness and erosion of root canal walls after irrigation with a new HEDP-based solution vs. traditional sodium hypochlorite followed by EDTA. A scanning electron microscope study
Kfir A, Goldenberg C, & Metzger Z, Hülsmann M, Baxter S
Clinical Oral Investigations (2020) 24:3699–3706
The efficacy of different irrigation protocols in removing tricalcium silicate-based sealers from simulated root canal irregularities
NV Ballal, Ö. Ulusoy, S. Rao, P. Ghandi
Dual Rinse® HEDP increases the surface tension of NaOCl but may increase its dentin disinfection efficacy
Luciano Giardino, Massimo Del Fabbro, Marco Morra,Thais Pereira, Flaviana Bombarda de Andrade, Paolo Savadori, Luigi Generali
Effects of endodontic irrigants on blood and blood-stained dentin
Adrian Zollinger, Thomas Attin, Dirk Mohn, Matthias Zehnder
Effects of endodontic irrigants on blood and blood-stained dentin (755.5 KiB)
Safety assessment of an etidronate in a sodium hypochlorite solution: randomized double-blind trial
Ballal V, Gandhi P, Shenoy P, Shenoy Belle V, Bhat V, Rechenberg DK, Zehnder M
Int Endod J. 2019 Apr 16. doi: 10.1111/iej.13129. [Epub ahead of print]
Chemical, cytotoxic and genotoxic analysis of etidronate in sodium hypochlorite solution
V. Ballal, S. Das, B. S. S. Rao, M. Zehnder, D. Mohn
Effect of Root Dentin Conditioning on the Pushout Bond Strength of Biodentine
Liz Paulson, BDS, Nidambur Vasudev Ballal, BDS, MDS, PhD, Abhishek Bhagat, MSc
Short-term storage stability of NaOCl solutions when combined with Dual Rinse HEDP.
Zollinger A, Mohn D, Zeltner M, Zehnder M.
Int Endod J. 2017 Nov 9. doi: 10.1111/iej.12875 [Epub ahead of print]
Several studies investigating the Dual Rinse HEDP continuous chelation concept are on their way.